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Medication: Diazepam (Generic Valium)
Tablet Strength: 10 mg
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Valium (Diazepam)

One of the most common and effective sedatives is Valium. The active ingredient in this drug is diazepam.

Pharmaceutical properties of the drug

The drug has a pronounced sedative, hypnotic, muscle relaxant, and anticonvulsant effect. During the period of use of the drug, vasodilatation, a decrease in blood pressure, and a decrease in paroxysms are noted.

The effect of the drug usually manifests itself on the 2-7th day of its administration. In people suffering from arrhythmia and cardialgia, a positive trend, as a rule, occurs at the end of the first week of using the remedy.

In the treatment of withdrawal symptoms that occur against the background of chronic alcoholism, the drug helps to get rid of limb tremors, hallucinations, agitation, and mental disorders.

Mechanism of action

Diazepam, which is part of Valium, has a pronounced anxiolytic activity. The drug eliminates the feeling of anxiety and fear, has a muscle relaxant and hypnotic effect.

The main effect of the drug is aimed at inhibiting the polysynaptic reflexes of the spinal cord. The drug lowers blood pressure, has a dilating effect on the coronary vessels, increases the pain threshold and increases the resistance of brain tissues to hypoxia.

It is effective in the treatment of withdrawal syndrome, as it helps the patient to relieve nervous tension, weaken the tremor of the limbs, and prevents the development and intensification of delirium and hallucinations.

Due to the ability to increase the pain threshold and reduce emotional stress in stressful situations, diazepam and preparations based on it are often used in anesthetic practice. It is prescribed to patients before surgeries and surgical procedures.

Wide application profile

In medical practice, Valium is prescribed for the treatment of such diseases:

  • anxiety disorders and stress;
  • sleep disturbance;
  • spasm of skeletal muscles;
  • dysphoria, myocardial infarction, arterial hypertension, gastrointestinal ulcers (as part of complex therapy);
  • cerebral palsy, tetanus, athetosis, and other spastic disorders;
  • angina pectoris;
  • arthrosis, accompanied by the tension of skeletal muscles;
  • myositis, arthritis, rheumatism, chronic polyarthritis;
  • vertebral syndrome;
  • hangover syndrome;
  • drug poisoning;
  • relief of epilepsy attacks;
  • Meniere’s disease;
  • skin diseases accompanied by itching.

The drug is used in gynecological practice for psychosomatic disorders during menopause and menstruation, as well as to alleviate the symptoms of preeclampsia and labor.

It is used to treat motor agitation and paranoid-hallucinatory states. Valium is prescribed as an analgesic for surgery and endoscopic procedures.

Overdose and side effects

Exceeding the daily dosage manifests itself in the form of CNS depression of varying severity – from drowsiness and confusion to hypotension, respiratory complications, and the onset of a coma.

You can relieve the symptoms of an overdose by causing the patient to vomit and taking the required amount of activated charcoal. If the patient is unconscious, then he should perform gastric lavage and introduce the antidote of benzodiazepine substances – Flumanesil.

Side effects from taking the drug include:

  • addiction;
  • decrease in the concentration of attention and deterioration of reaction;
  • violation of short-term memory;
  • dizziness;
  • headache;
  • disorder of the musculoskeletal system manifested in the form of dysarthria and ataxia;
  • decrease in arterial pressure;
  • allergic reactions.

Prolonged uncontrolled use of the drug can lead to disruption of the kidneys and liver, as well as reduce libido and lead to impotence.

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